Santa Vižine was born in Riga. She graduated from the Jāzeps Vītols Latvian Music Academy in 2011. The violist is a laureate of several Latvian and international competitions.  

From 2009 to the 2016/17 season, she was principal violist of Gidon Kremer’s chamber orchestra Kremerata Baltica. It brought the privilege of working with such soloists as Martha Argerich, Mikhail Pletnev, Daniil Trifonov, Lisa Batiashvili, Patricia Kopatchinskaja, Didier Lockwood, Mischa Maisky, Mate Bekavac and Sergei Nakariakov.  

In December 2017 Santa Vižine joined the violas of the Concertgebouw Orchestra. Since January 2022 she is first principal violist.